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Ellenberger, T. and Tomkinson, A.E. (2008) Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 77:313-338 [PubMed].

Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G.M., MacKerell, A.D. Jr and Tomkinson, A.E. (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68:3169-3177 [PubMed].

Cotner-Gohara, E., Kim, I.K., Tomkinson, A.E. and Ellenberger, T. (2008) Two DNA binding and nick recognition modules in human DNA ligase III. J. Biol. Chem. 283:10764-10772 [PubMed].

Tsodikov, O.V., Ivanov, D., Orelli, B., Staresincic, L, Shoshani, I., Oberman, R., Scharer, O.D., Wagner, G. and Ellenberger, T. (2007) Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J. 26:4768-4776 [PubMed].

Aihara, H., Huang, W.M. and Ellenberger, T. (2007) An interlocked dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telemeres. Mol Cell. 27:901-913 [PubMed].

Ivanov, D., Tsodikov, O.V., Kasanov, J., Ellenberger, T., Wagner, G. and Colins, T. (2007) Domain-swapped dimerization of the HIV-1 capsid C-terminal domain. Proc Natl Acad Sci USA 104:4353-4358 [PubMed].

Wang, X., Kennedy, R., Ray, K., Stuckert, P., Ellenberger, T. and D' Andrea, A.D. (2007) Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol 27:3098-3108 [PubMed].

Kowal, P., Gurtan, A.M., Stuckert, P., D'Andrea, A.D. and Ellenberger, T. (2007) Structural determinants of human FANCF protein that function in the assembly of DNA damage signaling complex. J. Biol Chem 282:2047-2055 [PubMed].

Pascal, J.M., Tsodikov, O.V., Hura, G.L., Song, W., Cotner, E.A., Classen, S., Tomkinson, A.E., Tainer, J.A. and Ellenberger, T. (2006) A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell 24:279-291 [PubMed].

Chen, X., Pascal, J., Vijayakumar, S., Wilson, G.M., Ellenberger, T. and Tomkinson, A.E. (2006) Human DNA ligases I, III, and IV--Purification and new specific assays for these enzymes. Methods in Enzymology 409:39-52 [PubMed].

King, D.A., Hall, B.E., Iwamoto, M.A., Win, K.Z., Chang, J.F. and Ellenberger, T. (2006) Domain structure and protein interactions of the silent information regulator SIR3 revealed by screening a nested deletion library of protein fragments. J Biol Chem 281:20107-20119 [PubMed].

Radman-Livaja, M., Biswas, T., Ellenberger, T., Landy, A. and Aihara, H. (2006) DNA arms do the legwork to ensure the directionality of lambda site-specific recombination. Curr Opin Struct Biol 16:42-50 [PubMed].

Tomkinson, A.E., Vijayakumar, S., Pascal, J.M. and Ellenberger, T. (2006) DNA ligases: Structure, reaction mechanism and function. Chem Rev 106:687-699 [PubMed].

Kim, T.W., Brieba, L.G., Ellenberger, T. and Kool, E.T. (2006) Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: Probing T7 DNA polymerase with variably sized base pairs. J Biol Chem 281:2289-2295 [PubMed].

Brieba, L.G., Kokoska, R.J., Bebenek, K., Kunkel, T.A., and Ellenberger, T. (2005). A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine. Structure 13, 1653-1659. [PubMed]

Cherepanov, P., Ambrosio, A.L., Rahman, S., Ellenberger, T., and Engelman, A. (2005). Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc. Natl. Acad. Sci. USA. Oct 31 2005 102:17308-17313. [PubMed]

Chan, B., Greenan, G., McKeon, F., and Ellenberger, T. (2005). Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc. Natl. Acad. Sci. USA. 102(37):13075-80. [PubMed]

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Iffland, A, Kohls, D, Low, S, Luan, J, Zhang, Y, Kothe, M, Cao, Q, Kamath, AV, Ding, YH, and Ellenberger, T. (2005). Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry 44, 8312-8325. [PubMed]

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Krejci, L., Macris, M., Komen, S.V., Villemain, J., Ellenberger, T., Klein, H., and Sung, P. (2004). Role of ATP hydrolysis in the anti-recombinase function of Saccharomyces cerevisiae Srs2 protein.   J. Biol. Chem. 279, 23193-23199. [PubMed]

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Krejci, L., Van Komen, S., Li, Y., Villemain, J., Reddy, M.S., Klein, H., Ellenberger, T., and Sung, P. (2003).   DNA helicase Srs2 disrupts the Rad51 presynaptic filament.   Nature 423, 234-235. [PubMed]

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Tekle, M., Warren, D. J., Biswas, T., Ellenberger, T., Landy, A., Nunes-Duby, S. E. (2002). Attenuating functions of the C terminus of lambda integrase.   J. Mol. Biol. 324, 649-665.

Sarkar, D., Azaro, M.A., Aihara, H., Papagiannis, C.V., Tirumalai, R., Nunes-Düby, S.E., Johnson R.C., Ellenberger, T., and Landy, A. (2002) Differential Affinity and Cooperativity Functions of the Amino-terminal 70 Residues of Lambda Integrase. J. Mol. Biol. 324, 775-789.

Goel, A., Ellenberger, T., Frank-Kamenetskii, M.D., and Herschbach, D. (2002). Unifying Themes in DNA Replication: Reconciling Single Molecule Kinetic Studies With Structural Data on DNA Polymerases.   J. Biomol. Struct. Dynamics 19, 571-584.

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Goel, A., Frank-Kamenetskii, M.D., Ellenberger, T., and Herschbach, D. (2001). Tuning DNA “Strings”: Modulating the Rate of DNA Replication With Mechanical Tension.   Proc. Natl. Acad. Sci. USA. 98, 8485-8489.

Hollis, T., Stattel, J.M., Walther, D.S., Richardson, C.C., & Ellenberger, T. (2001). Structure of the Gene 2.5 Protein, a Single-Stranded DNA Binding Protein Encoded by Bacteriophage T7.   Proc. Natl. Acad. Sci. USA. 98, 9557-9562.

Silvian, L.F.,   Toth, E.A., Pham, P., Goodman, M.F.,   & Ellenberger, T. (2001). Crystal Structure of a DinB Family Error-prone Polymerase from Sulfolobus Solfataricus.   Nature Struct. Biol.8, 984-989.

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Singleton, M.R., Sawaya, M.R., Ellenberger, T., and Wigley, D.B. (2000). Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides.   Cell 101, 589-600.

Hollis, T., Ichikawa, Y., and Ellenberger, T. (2000). DNA Bending and a Flip-out Mechanism for Base Excision by the Helix-hairpin-helix DNA Glycosylase, Escherichia coli AlkA.   EMBO J. 19, 758-766.

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